High Effective Sexual Functions Raw Powder / Hydrochloride For
Molecular formula C21H23NO. HCl
Molecular weight 341.88
Melting point 118-123°C
Character: White to Off-White Cyrstalline Solid, odorless, slight
Half life : 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose).
is a white powder substance and water-soluble. Taken 1-3 hours
before sexual activity, it is rapidly absorbed in the body. Its
maximum plasma concentration (Cm) is reached 1-2 hours after oral
can be taken with or without food.
is a selective serotonin reuptake inhibitor (SSRI) that was
designed specifically for premature ejaculation. SSRIs have been
shown to be effective for the treatment of PE. The downside to most
SSRIs is that they must be taken daily in order to achieve the
desired effect. was designed to be taken on an "as needed" basis
and has been shown to be effective when taken < 3 hours before
sexual activity. Studies have shown that increases the
intra-vaginal ejaculation latency time (IELT) - the time from
vaginal penetration to male orgasm.
, marketed as (among and other brands) is the first compound
developed specially for the treatment of premature ejaculation (PE)
for men at th age of 18-64 years old. works by inhibiting the
serotonin transporter, increasing serotonin's action at the post
synaptic cleft, so as to delay ejaculation.. As a member of
selective serotonin reuptake inhibitor (SSRI) family, was initially
created as an antidepressant. However, unlike other SSRIs, is
absorbed and eliminated rapidly in the body. Its fast response
makes it suitable for the treatment of PE but not as an
In Dresser study (2006), plasma concentration of 24 subjects was
obtained. Half of the sample pool were treated with 60 mg +
tadalafil 20 mg; the other half were treated with 60 mg + 100 mg.
These plasma samples were then analyzed using liquid
chromatography-tandem mass spectrometry. The results showed that
does not alter the pharmacokinetic of tadalafil .
Treat male premature ejaculation and erectile dysfunction.
Because lack of specific approval treatment for PE in the US and
some other countries, other SSRIs such as fluoxetine, paroxetine,
sertraline, fluvoxamine, and citalopram have been used as off label
drugs to treat PE.
Waldinger's meta analysis shows that the use of these conventional
antidepressants increasing IELT from two to ninefold above base
line in comparison of three to eightfold when is used. However,
these SSRIs must be taken daily in order to achieve meaningful
efficacy, and the long half-life increases the risk of the drug
accumulation and as a consequence increased of adverse effects such
as decreasing sexual libido and causing erectile dysfunction.
, on the other hand, is a fast-acting SSRI. It is rapidly absorbed
and eliminated from the body within a few hours. This favorable
pharmacokinetics minimizes the risk of the drug's accumulation in
the body, and therefore reducing side effects.
The News On Treat Premature Ejaculation:
To treat premature ejaculation, both psychological and
physiological factors need to be managed. From a pharmacological
point-of-view, to treat the physiological aspect of premature
ejaculation, hydrochloride is one of the first oral drugs to be
made available. Psychological treatment may be given concomitantly,
as the condition is multifactorial.
One of the possible adverse effects reported with SSRIs when used
to treat depression is delayed ejaculation. This reported adverse
effect led to the studies of hydrochloride, using the effect
therapeutically. It is thought that serotonin may be involved in
the inhibition of ejaculation. By blocking the serotonin reuptake
in men suffering from premature ejaculation, the time to
ejaculation may be prolonged.
|Characteristics||White or almost white crystalline powder||White crystalline powder|
|Loss on drying||≤0.5%||0.32%|
|Assay(on drled basis)||≥99.5%||99.61%|
|Conclusion||It complies to prescrlbed enterprise standard|