Treatment Pharmaceutical Raw Material Isotretinoin CAS 4759-48-2
For Severe Acne
Appearance: Orange Crystal Powder
Chemical Property: The melting point of 174 ~ 175 Centigrade. UV
maximum absorption: 354nm ( 39800). Acute toxicity of LD50 (20
days) mice, rats by intraperitoneal injection of:904901 (mg/kg);
3389 > 4000 oral.
Usage of Tretinoin:
Isotretinoin or 13-cis retinoic acid is a very effective medication
for the treatment of acne . It is a retinoid; this means it is
derived from vitamin-A (retinoic acid). The liver naturally makes
small quantities of isotretinoin from vitamin-A, but the drug we
prescribe is made synthetically.
Analysis for Isotretinoin:
|Name of Product||ISOTRETINOIN|
|Manufacturing Date||2012.10.16||Expiry Date||2014.10.16|
|Description||Yellow crystalline powder||complies|
|The IR absorption spectrum should correspond||complies|
|Should exhibits maximum absorption at 354nm||complies|
|Loss on drying||≤0.5%||0.07%|
|Residue on ignition||≤0.1%||0.02%|
|Conclusion||The product complies with USP34|
Due to sideeffects and high cost, isotretinoin is used primarily
for severe cystic acne and acne that has not responded to other
treatments. Acne treatment usually begins with topical medications
(e.g., benzoyl peroxide and adapalene), followed by oral
antibiotics and isotretinoin as a last resort.
Isotretinoin is used primarily for severe cystic acne and acne that
has not responded to other treatments Acne treatment usually begins
with topical retinoids (e.g., tretinoin, adapalene), in combination
with topical antibiotics (e.g., erythromycin) or antiseptics (e.g.,
benzoyl peroxide-containing preparations), followed by oral
antibiotics In women a cyproterone acetate-containing contraceptive
pill can be useful if there are no contraindications.
In cases of hormonal acne, such as in women in their 20s and 30s
with cyclical acne, often a course of isotretinoin can permanently
improve acne obviating the need for lifelong hormonal manipulation.
Isotretinoin's main indication is for the treatment of severe
cystic acne vulgaris.Many dermatologists also support its use for
treatment of lesser degrees of acne that prove resistant to other
treatments, or that produce physical or psychological scarring.
It is also somewhat effective for hidradenitis suppurativa and some
cases of severe acne rosacea. It can also be used to help treat
harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma
pigmentosum cases to relieve keratoses. Isotretinoin has been used
to treat the extremely rare condition fibrodysplasia ossificans
progressiva. It is also used for treatment of neuroblastoma, a form
of nerve cancer.
Isotretinoin therapy has furthermore proven effective against
genital warts in experimental use, but is rarely used due to
potentially severe side effects. In a small-scale study, low dose
oral isotretinoin showed considerable efficacy; Isotretinoin may
represent an efficacious and safe alternative systemic form of
therapy for RCA of the cervix. Yet, albeit this indicative evidence
not many studies have been conducted to further confirm its
effectivenes. In most countries this therapy is currently
unapproved and only used if other therapies failed.
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