Selective Androgen Receptor Modulator Powder GW501516 CAS
|Application||as a potential treatment for obesity, diabetes, dyslipidemia and
CAS No: 317318-70-0
Molecular Weight: 453.498
Appearance: White fine powder
An experimental drug meant to control lipids and increase the level
of HDL, or good cholesterol, in the bloodstream. A cell-permeable,
thiazolyl compound that acts as a potent, high affinity, PPAR
agonist. Exhibits selectivity for PPAR compared to PPAR and PPAR.
Does not exibit any activity against other nuclear or non-nuclear
receptors. Reported to increase cholesterol efflux and ABAC1
expression in macrophages, fibroblasts, and intestinal cells.
GW501516 (also known as GW-501,516, GW1516, GSK-516 and
Endurobol)is a PPAR receptor. It activates the same pathways
activated through exercise, including PPAR and AMP-activated
protein kinase. It had been investigated as a potential treatment
for obesity, diabetes, dyslipidemia and cardiovascular disease.
GW501516 has a synergistic effect when combined with AICAR: the
combination has been shown to significantly increase exercise
endurance in animal studies more than either compound alone.
GW501516 could be used by athletes as an ergogenic performance
enhancing drug that was not currently controlled by regulations or
detected by standard tests. One of the main researchers from the
study on enhanced endurance consequently developed a urine test to
detect the drug, and made it available to the International Olympic
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